Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

Building on the concept that blocking differentiation into specialized cell types maintains stem cells, USC and NIH scientists identify GSK3α as a checkpoint across diverse stem cell types. A study ...

Skin cancers, lung cancers, lymphomas—though these cancers affect different parts of the body, they can all be treated with one of the latest therapies medicine has to offer: checkpoint inhibitors.

Checkpoint inhibitors are antibody-based cancer therapies that unlock the immune system’s natural ability to fight cancer. These treatments work by blocking special proteins called immune checkpoints, ...

It's the cancer-fighting immune cells in a Merkel cell carcinoma patient's blood — not their tumor — that best predicts whether a certain type of immunotherapy will work, according to new work from ...

Yale researchers have uncovered a way to make a type of white blood cells known as natural killer cells — which kill infected, damaged, or malignant cells in the body — more effective against cancer.

Immune system activation and activity is regulated through stimulatory or inhibitory ligand-receptor interactions collectively termed immune checkpoints. 1 Stimulatory interactions give the immune ...

Red indicates mouse embryonic stem cells and green indicates mouse epiblast stem cells. The two cell types were co-cultured under GSK3α inhibition and maintained their distinct identities. A study ...